iPremom develops prenatal diagnostic solutions based on the identification of early molecular alterations associated with pregnancy complications. Our approach integrates:
The aim is to detect biological alterations before the appearance of clinical symptoms, allowing for early intervention.
Our research has identified a key mechanism in the development of preeclampsia:
These alterations generate a molecular signature detectable in maternal blood through cfRNA.
Our research has identified a key mechanism in the development of preeclampsia:
Decidualisation prepares the uterus for embryonic invasion and placental development. We have demonstrated the maternal contribution to severe preeclampsia through defective decidualisation.
The placenta provides nutrients and oxygen to the embryo. Defective decidualisation alters maternal-fetal communication during placentation.
cfRNA molecules reflect dynamic changes in the biology of pregnancy. Our technology makes it possible to detect these signals and predict complications before the appearance of symptoms.
iPremom's technology is based on an integrated pipeline:
Extraction of circulating cell-free RNA (cfRNA) from maternal plasma
Library preparation
Sequencing using NGS (Next-Generation Sequencing)
Quality control
Processing of transcriptomic data
Integration of clinical variables
Algorithm based on artificial intelligence
Generation of an individualised preeclampsia risk during the first trimester
iPremom's technology is based on an integrated pipeline: The system is implemented as:
Software-as-a-Medical-Device (SaMD)
Compliant with ISO 13485 and IEC 62304 standards
The development of the platform has been carried out progressively through:
This approach has made it possible to establish a direct relationship between:
biological origin → molecular signal → detection in blood
iPremom takes part in projects funded through competitive calls, which support the scientific and technological development of our solutions.
Consult publications, clinical studies and model validations.
